In human solid tumors, nodal status is the most important prognostic indicator for patientsβ outcome. Recent developments in the sentinel lymph node concept have resulted in a procedure to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System provides molecular oncologists, radiologists, and clinicians the necessary information to study and develop new strategies to curb the process of metastasis.
Written for: Medical, radiation, and surgical oncologists, pathologists, cancer biologists
Chapter 34
Targeting Signaling Pathways in Cancer Therapy Harold Wanebo
Part VII: Impact of Nodal Status and Tumor Burden in Sentinel Nodes on the Clinical Outcome
Chapter 35
Micrometastasis of Melanoma to SLNs - Stanley Leong
Chapter 36
Micrometastasis of Breast Cancer to SLNs - Markus Zuber
Chapter 37
Micrometastasis of Head and Neck Cancer to SLNs - Jochen Werner
Chapter 38
Micrometastasis of Genitounrinary Cancer to SLNs - Ramon Cabanas
Chapter 39
Micrometastasis of Colorectal Cancer to SLNs - Sukamal Saha
Chapter 40
Micrometastasis of Upper GI Cancer to SLNs - Yuko Kitagawa
Chapter 41
Application of Cancer Biology in Cancer Staging and Predicting Clinical Outcome - Frederick Greene
Chapter 42
Should Regional Lymph Node Dissection be done for Breast Cancer? Douglas Reintgen and Blake Cady
Part VIII: Immune Responses in the Draining Lymph Nodes Against Cancer: Implication for Immunotherapy
Chapter 43
Role of Lymph Nodes in Immunotherapy of Malignant Tumors - Suyu Shu
Chapter 44
Tumor-Related Immune Modulation of the Regional Lymph Nodes - Alistair Cochran and Rong-Rong Huang
Chapter 45
Reversal of Immune Suppression in Sentinel Lymph Nodes - Richard Essner
Chapter 46
Immunomodulation of the Sentinel Node and Systemic Immunity in Melanoma - Donald Morton
Chapter 47
Vaccine-Primed Lymph Node Cells in the Adoptive Immunotherapy of Cancer - Fred Chang
Chapter 48
Laboratory Monitoring of Immune Functions in Immunotherapy Trials Holden Maeker
Chapter 49
Strategies of Developing Cancer Immunotherapies - Karin Jooss Part IX: The Role of Stem Cells in Cancer Metastasis
Chapter 50
Stem Cells in Metastatic Melanoma - Ruby Ghadially
Chapter 51
Implications of Cancer Stem Cells for Metastasis - Michael Clarke
Chapter 52
Prostate Cancer Stem Cells: Identification, Characterization, Regulation of Self Renewal, and Involvement in Metastasis - Dean Tang
Part X: Genomic Signatures of Cancer: Basis for Selective Adjuvant Therapy
Chapter 53
Molecular Tecniques to Study Gene Profiles of Cancer - Dominick Sinicropi and Maureen Cronin
Chapter 54
Gene Signatures and Profiling in Cancer - Debjani Dutta
Chapter 55
Molecular Subgrouping of Breast Cancer Patients - Frederick Baehner
Chapter 56
Molecular Subgrouping of Colon Cancer Patients - Wayne Cowens
Chapter 57
Validating Gene Expression Signatures in Melanoma Mohammed Kashani- Sabet
Part XI: Promising New Treatments for Solid Tumors
Chapter 58
Targeted Therapy for Breast Cancer - Hope Rugo
Chapter 59
Signifigance of Circulating Tumor Cells in Breast Cancer and other Solid Tumors Research and Clinical Applications - Hope Rugo, John Park and Catherine Panabieres
Chapter 60
Advances in the Treatment of Colorectal Cancer: Targeting Receptors and Sites of Disease - Alan Venook
Chapter 61
Advances in the Treatment of Genitourinary Cancers - Charles Ryan
Chapter 62
Advances in the Treatment of Lung Cancer - Sarita Dubey
Part XII: Recent Advances in the Treatment of Melanoma
Chapter 63
Genomic Characterization of Malignant Melanoma - Boris Bastian
Chapter 64
Pegylated Interferons in the Adjuvant Treatment of Melanoma - Dirk Schadendorf
Chapter 65
Sorafenib, a Multi-kinase Inhibitor, in Metastatic Melanoma - Axel Hauschild
Chapter 66
Breaking Immune Tolerance: a Step Forward in Melanoma Treatment Antonio Ribas
Chapter 67
Cutaneous Metastases: New Treatment Options - Claus Garbe
Chapter 68
Neoadjuvant Approaches in Melanoma - John Kirkwood
Chapter 69
Chemo-/Biochemotherapy: Old Fashioned or Still a Standard of Care? Sanjiv Agarwala
Part XIII: Special Topics in Oncology
Chapter 70
Diagnosis and Intervention of Cancer: Vision of the National Cancer Institute-John E. Niederhuber
Chapter 71
The Pathogenesis of Organ-Tissue Specific Metastasis-Isaiah J. Fidler
Chapter 72
Lymphatic Mapping and Sentinel Lymphadenectomy: A Personal Journey-Donald Morton
Chapter 73
Vascular Endothelial Growth Factor Family, Cancer Biology and Treatment: From Bench to Bedside-Napoleon Ferrara
Chapter 74
Proliferation and Cancer Metastasis from the Clinical Point of View-Blake Cady
Chapter 75
Future Perspectives- Stanley Leong and Marlys Witte
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